Which chemotherapy drugs are radiosensitizers?
Radiation sensitizers include primarily traditional chemotherapy agents (i.e., gemcitabine, interferon-α, 13-cis-retinoic acid, doxorubicin, docetaxel, carboplatin, cisplatin, dactinomycin, methotrexate, 5-FU, bleomycin, and hydroxyurea).
Which drug is considered a radiosensitizer?
These drugs include nitroimidazole, misonidazole, etanidazole, nimorazole, and efaproxaril. 2. Hypoxic cytotoxins presumably play their role by selectively killing hypoxic cells, which are generally more resistant to radiation.
Is cisplatin a radiosensitizer?
Like cisplatin, carboplatin is an effective radiosensitizer in a variety of in vitro and in vivo systems, targeting the hypoxic cell population as well as potentiating cell kill after irradiation [32,33].
Is capecitabine a radiosensitizer?
Conclusion: Concurrent chemoradiation using capecitabine as a radiosensitizer in the adjuvant setting for pancreatic cancer was completed by the vast majority of patients in this series. Treatment was relatively well-tolerated, and its efficacy seems comparable to that for historical controls.
What does radiosensitizing mean?
Listen to pronunciation. (RAY-dee-oh-SEN-sih-TY-zer) Any substance that makes tumor cells easier to kill with radiation therapy. Some radiosensitizers are being studied in the treatment of cancer. Also called radiosensitizing agent.
How do radiosensitizers work?
Radiosensitizers are chemicals or pharmaceutical agents that can enhance the killing effect on tumor cells by accelerating DNA damage and producing free radicals indirectly. In most cases, radiosensitizers have less effect on normal tissues.
How do Radiosensitizers work?
Is Gemzar a radiosensitizer?
Abstract. Gemcitabine is a potent radiosensitizer in both laboratory studies and in the clinic. Initial laboratory studies showed that gemcitabine radiosensitizes a wide variety of rodent and human tumor cells in culture.